Not one but this airline has four major hubs
Santiago Comodoro International Airport in Santiago, Chile. São Paulo Guarulhos International Airport in São Paulo, Brazil. Jorge Chávez International Airport in Lima, Peru. And, El Dorado International Airport in Colombia. The aircrafts are flying over various regions including Europe, Latin America, and the North side of the America, Africa, and Oceania.
The headquarters are in Santiago, Chile meanwhile the focus cities are expanded throughout South America including Rio de Janeiro and Buenos Aires. The operational bases are covering Brazil, Colombia, Ecuador, Paraguay, and Peru.